Verapamil injections

Verapamil is a medication primarily known for its role in treating high blood pressure and other heart-related conditions. However, in recent years, the use of verapamil in an injectable form has garnered attention for its potential in treating certain medical conditions, such as Peyronie’s disease and plantar fibromatosis.

Verapamil Injections: Medical Uses

Verapamil injection must be administered under strict medical supervision in a healthcare setting, where professionals can monitor vital signs and heart rhythm to ensure safety and efficacy. The dosage and infusion rate are tailored to the individual’s health condition, with continuous monitoring for potential side effects such as dizziness, headache, or hypotension. Patients are advised to inform their healthcare providers about all medications they are taking to avoid adverse drug interactions.

Peyronie’s Disease

Peyronie’s disease is characterized by the formation of fibrous scar tissue in the penis, causing painful erections and curvature of the penis. Verapamil injections have been used as an off-label treatment to reduce the curvature and discomfort associated with this condition. The theory is that verapamil helps break down the scar tissue and reduce collagen production.

Plantar Fibromatosis

Plantar fibromatosis, also known as Ledderhose disease, involves the development of benign fibrous nodules in the arch of the foot. Verapamil injections are sometimes used to soften these nodules, thereby reducing pain and discomfort.

Mechanism of Action in Fibrotic Conditions

In conditions like Peyronie’s disease and plantar fibromatosis, verapamil is thought to interfere with the production of collagen and fibronectin, substances that contribute to the formation of fibrous tissues. Additionally, it may promote the increase of enzymes that break down these fibrous components.

Administration of Verapamil Injections

Verapamil injections for these conditions are typically administered directly into the affected tissue. The procedure is usually performed in a doctor’s office and may require multiple sessions over a period of time. The concentration of verapamil and the volume of each injection can vary based on the individual case and the doctor’s discretion.

Potential Side Effects and Considerations

While generally considered safe, verapamil injections can cause side effects, including local bruising, pain at the injection site, dizziness, and nausea. In rare cases, systemic effects such as hypotension (low blood pressure) may occur, especially if the drug is absorbed into the bloodstream in significant amounts.

Research and Efficacy

The efficacy of verapamil injections for Peyronie’s disease and plantar fibromatosis is still a subject of ongoing research. Some studies have shown positive outcomes, while others suggest the need for more extensive clinical trials to establish its effectiveness conclusively.

What side effects may I notice from receiving this medication?

Receiving Verapamil injection can lead to various side effects, though not everyone experiences them. The severity and occurrence of these effects can vary based on individual response, dosage, and treatment duration. Common side effects include:

  1. Dizziness or lightheadedness: This is often more pronounced when standing up from a sitting or lying position due to blood pressure changes.
  2. Headache: A common side effect that usually diminishes as your body adjusts to the medication.
  3. Nausea and constipation: Gastrointestinal issues are relatively common but can often be managed with dietary adjustments or medication.
  4. Fatigue or tiredness: Feeling unusually tired or weak is possible, especially in the initial stages of treatment.
  5. Edema (swelling): Swelling in the feet or ankles due to fluid accumulation is a possible side effect.
  6. Bradycardia (slow heart rate): As a medication affecting heart rhythm, Verapamil can cause your heart rate to slow down.
  7. Hypotension (low blood pressure): Symptoms might include dizziness, fainting, and blurred vision.

Serious side effects are less common but require immediate medical attention if they occur:

  • Severe hypotension or bradycardia
  • Signs of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain)
  • Severe dizziness or fainting
  • Severe rash, itching, or hives
  • Difficulty breathing or swallowing


Verapamil injections represent an innovative approach to treating certain fibrotic conditions, offering an alternative to more invasive surgical procedures. However, patients considering this treatment should consult with their healthcare provider to understand the potential benefits and risks. Ongoing research and clinical trials will continue to shed light on the effectiveness and safety of verapamil injections in various medical applications.