Squamous Cell Carcinoma

Squamous Cell Carcinoma (SCC) is a common type of skin cancer that originates in the squamous cells. These cells are flat, thin cells found in the outer layer of the skin (epidermis). SCC can occur in various parts of the body, including the skin, lips, mouth, esophagus, bladder, prostate, lungs, and cervix.

Symptoms of Squamous Cell Carcinoma

SCC can present in several ways, depending on its location. Common symptoms include:

  • Skin Lesions: Persistent, thick, rough, scaly patches that may bleed or crust over.
  • Open Sores: Non-healing sores that may bleed, itch, or produce a discharge.
  • Red Patches: Rough, scaly red patches that can be mistaken for eczema or psoriasis.
  • Wart-like Growths: Growths that resemble warts but are often larger and more persistent.
  • Lumps or Nodules: Firm, red nodules that can be painful.

Causes and Risk Factors

SCC is primarily caused by DNA damage in squamous cells, often due to ultraviolet (UV) radiation from the sun or tanning beds. Other factors that can contribute to the development of SCC include:

  • Chronic Sun Exposure: Long-term exposure to UV radiation is the most significant risk factor.
  • Fair Skin: Individuals with fair skin, light hair, and light eyes are more susceptible.
  • Age: SCC is more common in older adults, as the cumulative effect of sun exposure increases with age.
  • Gender: Men are more likely to develop SCC than women, possibly due to more outdoor activities and sun exposure.
  • History of Sunburns: Severe sunburns, especially during childhood, increase the risk.
  • Weakened Immune System: Conditions or medications that suppress the immune system can increase the risk of SCC.
  • Exposure to Carcinogens: Exposure to certain chemicals, such as arsenic, can increase the risk.
  • Previous Skin Cancer: Having had other forms of skin cancer increases the risk of developing SCC.

Diagnosis of Squamous Cell Carcinoma

Diagnosing SCC involves several steps:

  • Physical Examination: A dermatologist examines the skin for suspicious lesions.
  • Biopsy: A sample of the lesion is taken and examined under a microscope to confirm the diagnosis.
  • Imaging Tests: In advanced cases, imaging tests like CT scans or MRIs may be used to determine the extent of the cancer.

Treatment Options

Treatment for SCC depends on the size, location, and stage of the cancer. Common treatments include:

  • Surgical Excision: Removing the cancerous tissue along with some healthy tissue to ensure clear margins.
  • Mohs Surgery: A precise surgical technique where layers of cancer-containing skin are progressively removed and examined until only cancer-free tissue remains.
  • Curettage and Electrodessication: Scraping away the cancer cells followed by burning the area with an electric needle.
  • Cryotherapy: Freezing the cancer cells with liquid nitrogen.
  • Radiation Therapy: Using high-energy radiation to kill cancer cells, often used for tumors in difficult-to-treat areas.
  • Topical Treatments: Applying medicated creams or ointments to the affected area.
  • Photodynamic Therapy: Using light-activated drugs to destroy cancer cells.
  • Systemic Treatments: In advanced cases, chemotherapy or targeted drug therapy may be necessary.

Prevention Tips

Preventing SCC involves minimizing exposure to known risk factors:

  • Sun Protection: Use broad-spectrum sunscreen with an SPF of 30 or higher, wear protective clothing, and seek shade during peak sun hours.
  • Avoid Tanning Beds: Tanning beds significantly increase the risk of skin cancer.
  • Regular Skin Checks: Perform self-examinations and visit a dermatologist for regular skin checks, especially if you have a history of skin cancer.
  • Avoiding Carcinogens: Limit exposure to harmful chemicals and radiation.
  • Healthy Lifestyle: Maintain a healthy immune system through a balanced diet, regular exercise, and avoiding smoking.


Squamous Cell Carcinoma is a serious but treatable form of skin cancer. Early detection and treatment are crucial for a positive outcome. By understanding the symptoms, causes, and risk factors, and by taking preventive measures, you can reduce your risk of developing SCC.
If you notice any suspicious skin changes, consult a healthcare professional promptly for evaluation and possible treatment.