Testosterone Deficiency

Need help now?

Testosterone deficiency, often referred to as low testosterone or hypogonadism, is a medical condition characterized by inadequate levels of the male sex hormone testosterone in the body. This hormonal imbalance can lead to a range of symptoms, including fatigue, reduced muscle mass, low libido, and mood disturbances.

At the University of Kansas Department of Urology, our expert team is dedicated to providing top-tier care for testosterone deficiency. We work closely with each patient to create a customized treatment plan tailored to their specific needs, utilizing cutting-edge techniques and state-of-the-art diagnostics.

Types of Testosterone Deficiency

  • Primary Hypogonadism: This occurs when there is a problem with the testicles themselves, leading to insufficient testosterone production. Common causes include genetic conditions, testicular injury, chemotherapy, or radiation therapy.
  • Secondary Hypogonadism: Secondary hypogonadism occurs when there is a problem with the parts of the brain (the hypothalamus or pituitary gland) that regulate testosterone production. This can be due to issues such as tumors, head trauma, or certain medications.



The symptoms of testosterone deficiency can vary in severity and may include:

  • Low Sex Drive: A reduced interest in sexual activity or a decrease in sexual desire.
  • Erectile Dysfunction: Difficulty achieving or maintaining an erection.
  • Fatigue: Persistent tiredness and low energy levels.
  • Depression: Mood changes, including feelings of sadness and irritability.
  • Reduced Muscle Mass: Difficulty in building and maintaining muscle mass, along with weakness.
  • Increased Body Fat: A tendency to gain weight, especially around the abdomen.
  • Reduced Bone Density: Weakening of bones, which can lead to an increased risk of fractures.
  • Hair Loss: Thinning of facial and body hair.
  • Memory and Cognitive Problems: Difficulty with concentration and memory.
  • Sleep Disturbances: Insomnia or disrupted sleep patterns.


There are various causes of testosterone deficiency, and they can be classified into primary and secondary causes:

Primary Causes:

  • Age: Natural aging, especially in older men, can lead to a gradual decline in testosterone levels.
  • Testicular Conditions: These include genetic disorders (e.g., Klinefelter syndrome), injuries, or infections that affect the testicles.
  • Testicular Cancer: Cancerous growths in the testicles can impair testosterone production.
  • Chemotherapy or Radiation: Cancer treatments can damage the testicles and reduce testosterone production.

Secondary Causes:

  • Hypothalamus or Pituitary Disorders: Tumors, infections, or other issues affecting the hypothalamus or pituitary gland can disrupt the signaling process that stimulates testosterone production.
  • Certain Medications: Some medications, such as opioids and steroids, can lower testosterone levels.
  • Chronic Illness: Conditions like obesity, diabetes, or chronic kidney or liver disease can contribute to testosterone deficiency.
  • Stress and Obesity: Chronic stress and obesity can negatively impact hormone levels.
  • Lifestyle Factors: An unhealthy diet, lack of exercise, and excessive alcohol consumption can contribute to low testosterone levels.

Treatment for testosterone deficiency may involve hormone replacement therapy (HRT) to restore testosterone levels to a healthy range. It’s essential to consult a healthcare professional if you suspect you have testosterone deficiency, as they can diagnose the condition and recommend an appropriate treatment plan tailored to your specific needs.


Diagnosing testosterone deficiency typically involves a combination of clinical evaluation, medical history assessment, and laboratory tests. This can include the following:

  • Medical History: Your healthcare provider will ask about your symptoms, medical history, and any medications you’re taking.
  • Physical Examination: A physical exam may be conducted to look for signs of testosterone deficiency, such as changes in body composition, muscle mass, or the presence of gynecomastia (enlarged breast tissue).
  • Blood Tests: The primary diagnostic tool is a blood test to measure your testosterone levels. This test is usually done in the morning when testosterone levels are highest. Low testosterone levels, especially in combination with symptoms, can confirm the diagnosis.
  • Additional Tests: Sometimes, other tests may be ordered to determine the cause of the deficiency or rule out other underlying medical conditions. These may include tests to check for pituitary or hypothalamic issues, genetic testing, or imaging studies like MRI.


Treatment for testosterone deficiency aims to raise testosterone levels back to a healthy range and alleviate symptoms. The choice of treatment depends on the underlying cause and individual patient factors:

  • Testosterone Replacement Therapy (TRT): TRT involves the administration of synthetic testosterone, often in the form of injections, gels, patches, or implants. This helps restore testosterone levels to normal and can alleviate symptoms.
  • Lifestyle Modifications: In some cases, making lifestyle changes such as adopting a healthier diet, regular exercise, stress management, and weight loss can help improve testosterone levels, especially if obesity or other lifestyle factors are contributing to the deficiency.
  • Treatment of Underlying Conditions: If the deficiency is due to an underlying medical condition, such as diabetes or obesity, managing and treating that condition may help improve testosterone levels.
  • Medication Adjustments: If medication side effects are causing low testosterone, your doctor may adjust your medication regimen or explore alternative options.
  • Surgery: In cases of testicular conditions like tumors or certain congenital abnormalities, surgical intervention may be necessary.


The outlook for individuals with testosterone deficiency depends on several factors, including the underlying cause, the effectiveness of treatment, and the individual’s overall health. In many cases, with appropriate treatment, individuals can experience significant improvements in their symptoms and overall well-being. However, it’s essential to note the following:

  • Monitoring: Regular follow-up with a healthcare provider is crucial to monitor treatment progress, adjust therapy as needed, and ensure there are no adverse effects.
  • Long-Term Management: For many individuals, especially those on TRT, treatment may need to continue indefinitely to maintain normal testosterone levels and symptom relief.
  • Side Effects: TRT may have potential side effects, and its use should be carefully monitored. It’s essential to discuss the risks and benefits with your healthcare provider.
  • Individual Variability: Responses to treatment can vary among individuals, and not everyone may experience the same degree of improvement in symptoms.

Prevention & Management

While it may not always be possible to prevent testosterone deficiency, there are steps individuals can take to manage their condition and improve their overall well-being:

  • Lifestyle Modifications: Maintain a healthy lifestyle by eating a balanced diet, engaging in regular physical activity, managing stress, and getting enough sleep. These measures can help optimize testosterone levels and overall health.
  • Regular Check-Ups: Schedule routine medical check-ups to monitor your health and testosterone levels, especially if you have risk factors or symptoms of testosterone deficiency.
  • Medication Adherence: If you’re undergoing testosterone replacement therapy (TRT), follow your healthcare provider’s instructions carefully and attend follow-up appointments to ensure the therapy is effective and safe.
  • Manage Underlying Conditions: If you have underlying medical conditions contributing to testosterone deficiency, such as obesity, diabetes, or chronic illness, work closely with your healthcare team to manage and treat these conditions effectively.
  • Avoid Excessive Alcohol and Substance Use: Excessive alcohol consumption and drug use, including anabolic steroids, can disrupt hormone balance and exacerbate testosterone deficiency. Avoid or limit these substances.
  • Emotional Support: Seek emotional support and counseling if you experience mood changes or depression as a result of testosterone deficiency. Mental health support can be an essential part of overall management.
  • Bone Health: Pay attention to your bone health, especially if you’re at risk of osteoporosis due to low testosterone levels. Ensure you get enough calcium and vitamin D in your diet and consider weight-bearing exercises.


Testosterone deficiency, or hypogonadism, is a medical condition that can significantly impact a person’s quality of life. However, with proper diagnosis and management, many individuals can find relief from their symptoms and lead fulfilling lives. Early detection through regular check-ups, a healthy lifestyle, and adherence to prescribed treatments are essential steps in managing this condition.

For more information on Testosterone Deficiency